Iron-catalyzed Light-driven Decarboxylative Alkoxyamination

M. Innocent, C. Tanguy, S. Gavelle, T. Aubineau, A. Guérinot
Chem. Eur. J. 2024, 30, e20241252, https://doi.org/10.1002/chem.202401252

An iron-catalyzed, visible-light induced decarboxylative alkoxyamination of carboxylic acids with TEMPO is disclosed. In the presence of FeBr2 and TEMPO, a large array of carboxylic acids including marketed drugs and biobased molecules is turned into the corresponding alkoxyamine derivatives. The versatility of the latter offers an entry towards molecular diversity generation from abundant starting materials and catalyst. Overall, this method proposes a unified and general approach for LMCT-based iron-catalyzed decarboxylative functionalization.